THE SUCRE LAB
studying lung development, injury, and regeneration across the lifespan
We study normal lung development and the abnormal lung development that occurs after preterm birth.
We use in vitro, ex vivo, and in vivo tools to help us understand the molecular mechanisms that drive the pathogenesis of bronchopulmonary dysplasia, a leading complication in survivors of prematurity.
Our understanding of normal lung development helps us understand
acute and chronic lung disease across the human lifespan.
MODELING THE LUNG
We have developed 3D human organotypic models and murine ex vivo and in vivo models to study epithelial-mesenchymal interactions during lung development and lung injury.
UNDERSTANDING DEVELOPMENTAL PATHWAYS IN THE CONTEXT OF INJURY AND REPAIR
After injury, developmental pathways are reactivated to facilitate tissue regeneration and repair. Understanding how the pathways are regulated in the lung will provide the foundation for new targeted therapies to promote normal lung growth and regeneration.
COMPLEX BIOLOGY AT SINGLE CELL RESOLUTION
Using single-cell RNA transcriptomics, we seek to identify the populations of cells regulating normal lung development and the cell types driving abnormal repair after injury.