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THE SUCRE LAB

studying lung development, injury, and regeneration across the lifespan

RESEARCH

We study normal lung development and the abnormal lung development that occurs after preterm birth.

We use in vitro, ex vivo, and in vivo tools to help us understand the molecular mechanisms that drive the pathogenesis of bronchopulmonary dysplasia, a leading complication in survivors of prematurity.

Our understanding of normal lung development helps us understand

acute and chronic lung disease across the human lifespan.

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MODELING  LUNG DEVELOPMENT IN 4D

We have developed a 4-dimensional live imaging platform to study alveologenesis across space and time, leading to new insights about the cellular and molecular drivers of lung development and lung repair after injury

RARE DISEASES LEAD TO INSIGHTS ABOUT COMMON LUNG CONDITIONS

Sometimes rare genetic mutations (e.g. TBX4, FOXF1) can lead to developmental diseases that resemble the abnormal lung development after preterm birth. Studying these lung diseases helps us understand patients with rare conditions and more common conditions, such as bronchopulmonary dysplasia

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UNDERSTANDING DEVELOPMENTAL PATHWAYS IN THE CONTEXT  OF INJURY AND REPAIR

After injury, developmental pathways are reactivated to facilitate tissue regeneration and repair. Understanding how the pathways are regulated in the lung will provide the foundation for new targeted therapies to promote normal lung growth and regeneration.

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COMPLEX BIOLOGY AT SINGLE CELL RESOLUTION

Using single-cell RNA transcriptomics, we seek to identify the populations of cells regulating normal lung development and the cell types driving abnormal repair after injury.

CONTACT US

2215 Garland Ave, 1115 Light Hall
Nashville, TN 37232

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